منابع مشابه
Virus fuels NK cell killing of leukemia.
NK cell transplants have emerged as a potentially powerful approach to treating acute myeloid leukemia. Approaches that could be applied to enhance the NKmediated killing of leukemic cells would therefore have direct clinical importance. Oncolytic viral therapies have also shown promise in the treatment of a variety of solid cancers, leading to the recent approval of the oncolytic HSV talimogen...
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n page 987, Yu et al. identify a novel cell death pathway that bypasses mito-chondria. The results indicate that various strategies exist to kill off neurons. A lot of the killing of sympathetic neurons occurs in the first week after birth. During that paring period, ف 50% of sympathetic neurons die due to a lack of nerve growth factor (NGF). Neurons deprived of NGF in vitro die through the c...
متن کاملBlastic NK-Cell Leukemia / Lymphoma
Blastic natural killer (NK) cell lymphoma / leukemia is a rare NK cell malignancy of unknown etiology. It occurs in multiple sites and with a propensity for skin involvement. We report such a case in a 35-year-old male suffering from erythematous and purpuric papules and plaques on his face and trunk for 6 months. A biopsy specimen of the skin showed diffuse infiltration of blastlike lymphoid c...
متن کاملWhat Fuels Natural Killers? Metabolism and NK Cell Responses
There is a growing appreciation that cellular metabolism is important in determining the course of lymphocyte responses. Additionally, changes in metabolic processes have been linked to dysfunctional lymphocyte functions in a number of different diseases. While most early studies of metabolic regulation of lymphocyte function focused on T lymphocytes, an understanding of how metabolic pathways ...
متن کاملKilling begets killing: evidence from a bug-killing paradigm that initial killing fuels subsequent killing.
Killing appears to perpetuate itself even in the absence of retaliation. This phenomenon may occur in part as a means to justify prior killing and so ease the threat of prior killing. In addition, this effect should arise particularly when a killer perceives similarity to the victims because similarity should exacerbate threat from killing. To examine these ideas, the authors developed a bug-ki...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-03-704247